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Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patients

12 Jan 2025

Abstract excerpt

The tertiary lymphoid structure (TLS) is recognized as a potential prognosis factor for breast cancer and is strongly associated with response to immunotherapy. Inducing TLS neogenesis can enhance the immunogenicity of tumors and improve the efficacy of immunotherapy. However, our understanding of TLS associated region at the single-cell level remains limited. Therefore, we employed high-resolution techniques,...

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PMID: 39806382
DOI: 10.1186/s12935-025-03635-y

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