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Clonal expansion of intra‐epithelial T cells in breast cancer revealed by spatial transcriptomics

12 Jun 2023

Abstract excerpt

The spatial distribution of tumor-infiltrating lymphocytes (TIL) predicts breast cancer outcome and response to systemic therapy, highlighting the importance of an intact tissue structure for characterizing tumors. Here, we present ST-FFPE, a spatial transcriptomics method for the analysis of formalin-fixed paraffin-embedded samples, which opens the possibility of interrogating archival tissue. The method...

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PMID: 37306359
DOI: 10.1002/ijc.34620

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