Article

Stressed Actin Binding by the Prickle2 LIM Domains and its Regulation in the Full-Length Protein

2025-06-02

Abstract excerpt

Cells are capable of sensing mechanical changes in their cytoskeletal network via stress-sensitive actin-binding proteins. Recently, a novel stress-sensing mechanism was described whereby LIM domains from diverse protein families bind directly to stressed actin filaments. It remains unclear, however, how the interaction of these domains with actin is regulated in the context of full-length proteins. Here, we show...

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Literature Corpus work: 1744a5b3-ee25-52c9-868c-6c835f04074b
DOI: 10.1101/2025.05.30.657073

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