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Article

Intracellular pH modulation of ADF/cofilin proteins.

Cell motility and the cytoskeleton - 1 Dec 2000

Bernstein B W, Painter W B, Chen H, Minamide L S, Abe H, Bamburg J R

Abstract excerpt

The ADF/cofilin (AC) proteins are necessary for the high rates of actin filament turnover seen in vivo. Their regulation is complex enough to underlie the precision in filament dynamics needed by stimulated cells. Disassembly of actin by AC proteins is inhibited in vitro by phosphorylation of ser3 and pH<7.1. This study of Swiss 3T3 cells demonstrates that pH also affects AC behavior in vivo: (1) Wounded cells...

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Identifiers

PMID: 11093252
DOI: 10.1002/1097-0169(200012)47:4<319::AID-CM6>3.0.CO;2-I

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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