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The Notch/snRNA negative feedback regulation and its implications in Alzheimer’s disease

2025-12-10

Abstract excerpt

Alzheimer’s disease (AD) is a multifactorial disorder whose hallmark lesions have been recognized for more than a century, yet its molecular pathobiology remains fragmentary. During our AD research, we discovered a direct mechanistic axis that links the Notch signalling pathway — a crucial regulator of cell differentiation and proliferation—with the small nuclear RNAs (snRNAs) that drive pre-mRNA splicing. For the...

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Identifiers and source

Literature Corpus work
4478440b-e748-5cf0-8c8a-2abff3df4aa4
DOI
10.64898/2025.12.05.692707
Open publication

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The Notch/snRNA negative feedback regulation and its implications in Alzheimer’s diseaseDOI 10.64898/2025.12.05.692707
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