Article

Increased processing of SINE B2 non coding RNAs unveils a novel type of transcriptome de-regulation underlying amyloid beta neuro-pathology

2020-07-21

Abstract excerpt

<h4>ABSTRACT</h4> More than 97% of the mammalian genome is non-protein coding, and repetitive elements account for more than 50% of noncoding space. However, the functional importance of many non-coding RNAs generated by these elements and their connection with pathologic processes remains elusive. We have previously shown that B2 RNAs, a class of non-coding RNAs that belong to the B2 family of SINE repeats, medi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f4bdc10-8222-5858-b659-d60a5ddc6c55
DOI: 10.1101/2020.07.20.212886

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased processing of SINE B2 non coding RNAs unveils a novel type of transcriptome de-regulation underlying amyloid beta neuro-pathologyDOI 10.1101/2020.07.20.212886Read

Differential adenosine to inosine RNA editing of SINE B2 non-coding RNAs in mouse unveils a novel type of epi-transcriptome response to amyloid beta neuro-toxicitySemantic proximity Read

Warning SINEs: <i>Alu</i> elements, evolution of the human brain, and the spectrum of neurological diseaseSemantic proximity Read

RNA dysregulation and compromised neuronal identity drive pathogenesis in Senataxin-associated ALSSemantic proximity Read

The Notch/snRNA negative feedback regulation and its implications in Alzheimer’s diseaseSemantic proximity Read

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretaseSemantic proximity Read

Ataxin-2: From RNA Control to Human Health and DiseaseSemantic proximity Read

tRNA-derived fragments are elevated in the aging brain and may contribute to neurodegenerationSemantic proximity Read

Profiling Analysis of Circular RNA and mRNA in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis ILAE Type 1Semantic proximity Read

Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival.Semantic proximity Read

Involvement of transposable elements in Alzheimer’s disease pathogenesisSemantic proximity Read

The emerging role of pre-messenger RNA splicing in stress responses: sending alternative messages and silent messengers.Semantic proximity Read

Pur-alpha participates in the progression of Alzheimer's disease through direct and indirect waysSemantic proximity Read