Article

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing

2018-05-21

Abstract excerpt

Alternative splicing of pre-mRNAs plays a pivotal role during the establishment and maintenance of human cell types. Characterizing the trans -acting regulatory proteins that control alternative splicing in both healthy and malignant cells has therefore been the focus of much research. Recent work has established that even core protein components of the spliceosome, which are required for splicing to proceed, can...

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Literature Corpus work: 010685fa-cdb9-5c3a-a189-dcfd77179a62
DOI: 10.1101/326983

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