Article

ImmTACs overcome cytotoxic T cell suppression

2026-03-22

Abstract excerpt

Immune mobilizing monoclonal TCR against cancer (ImmTAC) are cancer therapeutics that activate T cells through recognition of a tumor-associated antigenic MHC/peptide complex. A first-in-class ImmTAC, Tebentafusp, is approved for the treatment of metastatic uveal melanoma. While clinical efficacy is thus established, the cellular mechanisms underpinning ImmTAC action are not fully resolved. Using a recently establ...

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Literature Corpus work: e41af50e-a972-58a3-baa3-6b8469fdf82b
DOI: 10.64898/2026.03.20.713194

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