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A single N6-methyladenosine site in lncRNA HOTAIR regulates its function in breast cancer cells

2020-06-09

Abstract excerpt

N6-methyladenosine (m6A) modification of RNA plays important roles in normal and cancer biology, but knowledge of its function on long noncoding RNAs (lncRNAs) remains limited. Here, we investigate whether m6A regulates the function of the human HOTAIR lncRNA, which contributes to multiple pro-tumor phenotypes in triple-negative breast cancer (TNBC) cells. We identify at least 8 individual m6A sites within HOTAIR,...

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Literature Corpus work
40ce5f64-a7bf-57da-8c2a-0a6e47761711
DOI
10.1101/2020.06.08.140954
Open publication

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A single N6-methyladenosine site in lncRNA HOTAIR regulates its function in breast cancer cellsDOI 10.1101/2020.06.08.140954
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