Article

Epilepsy kinase CDKL5 is a DNA damage sensor which controls transcriptional activity at DNA breaks

2020-12-11

Abstract excerpt

Mutation of the CDKL5 kinase gene leads to the seizure-prone neurodevelopmental condition CDD (CDKL5 deficiency disorder) and is the most common genetic cause of childhood epilepsy. However, the phospho-targets and roles of CDKL5 are poorly understood, especially in the nucleus. We reveal CDKL5 as a sensor of DNA damage in actively transcribed regions of the nucleus, which phosphorylates transcriptional regulator...

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Literature Corpus work: 444b1f2b-ebb8-5a36-bdfa-14f26245c4b4
DOI: 10.1101/2020.12.10.419747

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