Article

Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope

2023-05-11

Abstract excerpt

Repair of DNA Double-Strand Breaks (DSBs) produced in transcriptionally active chromatin occurs through a poorly characterized pathway called Transcription-Coupled DSB repair (TC-DSBR). Here, using a screening approach scoring multiple outputs in human cells, we identified proteins from the PERIOD complex, a key module ensuring circadian oscillations, as novel TC-DSBR players. We show that the core PER complex pro...

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Identifiers and source

Literature Corpus work: e9f23f62-ef3e-5671-9fa1-d3a30a28f668
DOI: 10.1101/2023.05.11.540338

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