Article

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex development

2026-04-07

Abstract excerpt

Loss-of-function mutations in the X-linked CDKL5 gene lead to a severe neurodevelopmental disorder characterized by early-onset epilepsy, known as CDKL5 Deficiency Disorder (CDD). Despite its clinical significance, the physiological substrates of the serine/threonine kinase CDKL5 and its roles in neuronal development remain poorly understood. To address this, we performed quantitative phosphoproteomics analysis in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db3f726a-d853-5b17-bb6a-7d9034675bc5
DOI: 10.64898/2026.04.07.716766

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex developmentDOI 10.64898/2026.04.07.716766Read

CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.Semantic proximity Read

Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder.Semantic proximity Read

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.Semantic proximity Read

Transcriptomic Profiling of Zebrafish Mutant for cdkl5 Reveals Dysregulated Gene Expression Associated with Neuronal, Muscle, Visual and Skeletal DevelopmentSemantic proximity Read

What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.Semantic proximity Read

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitabilitySemantic proximity Read

Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development.Semantic proximity Read

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.Semantic proximity Read

Mapping pathological phenotypes in a mouse model of CDKL5 disorder.Semantic proximity Read

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiologySemantic proximity Read

Altered Short Non-Coding RNAs Landscape in the Hippocampus of a Mouse Model of CDKL5 Deficiency DisorderSemantic proximity Read

The CDKL5 kinase undergoes liquid-liquid phase separation driven by a serine-rich C-terminal region and impaired by neurodevelopmental disease-related truncationsSemantic proximity Read