Article

<i>In Vivo</i> Proximity Labeling Identifies a New Function for the Lifespan and Autophagy-regulating Kinase Pef1, an Ortholog of Human Cdk5

2024-06-14

Abstract excerpt

<h4>ABSTRACT</h4> Cdk5 is a highly-conserved, noncanonical cell division kinase important to the terminal differentiation of mammalian cells in multiple organ systems. We previously identified Pef1, the Schizosaccharomyces pombe ortholog of cdk5, as regulator of chronological lifespan. To reveal the processes impacted by Pef1, we developed APEX2-biotin phenol-mediated proximity labeling in S. pombe. Efficient l...

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Literature Corpus work: b8439985-6fa2-59e1-80fa-b02076c191bf
DOI: 10.1101/2024.06.12.598664

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