Article
CDKL5 kinase controls transcription-coupled responses to DNA damage.
The EMBO journal - 1 Dec 2021
Khanam Taran, Muñoz Ivan, Weiland Florian, Carroll Thomas, Morgan Michael, Borsos Barbara N, Pantazi Vasiliki, Slean Meghan, Novak Miroslav, Toth Rachel, Appleton Paul, Pankotai Tibor, Zhou Houjiang, Rouse John
Abstract excerpt
Mutations in the gene encoding the CDKL5 kinase are among the most common genetic causes of childhood epilepsy and can also give rise to the severe neurodevelopmental condition CDD (CDKL5 deficiency disorder). Despite its importance for human health, the phosphorylation targets and cellular roles of CDKL5 are poorly understood, especially in the cell nucleus. Here, we report that CDKL5 is recruited to sites of...
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