Article

Unraveling the heterogeneous mutational signature of spontaneously developing tumors in MLH1 <sup>-/-</sup> mice

2019-08-05

Abstract excerpt

MLH1 knock out mice represent a preclinical model that resembles features of the human counterpart. As these mice develop mismatch repair deficient (MMR-D) neoplasias in a sequential twin-peaked manner (first lymphomas, then gastrointestinal tumors) we aimed at identification of the underlying molecular mechanisms. Using whole-exome sequencing, we focused on (I) shared and (II) mutually exclusive mutations and des...

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Literature Corpus work: 44361b29-1a39-55ca-8580-56aaa96d7ccb
DOI: 10.1101/725929

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