Article

Tracking Subclonal Mutation Frequencies Throughout Lymphomagenesis Identifies Cancer Drivers in Mouse Models of Lymphoma

2017-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Determining whether recurrent but rare cancer mutations are bona fide driver mutations remains a bottleneck in cancer research. Here we present the most comprehensive analysis of retrovirus driven lymphomagenesis produced to date, sequencing 700,000 mutations from >500 malignancies collected at time points throughout tumor development. This enabled identification of positively selected events, a...

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Literature Corpus work: 29d1e3ca-9d6f-5b2a-890e-d593fe80c677
DOI: 10.1101/157800

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