Article

Molecular Characterization of Mismatch Repair Deficient Tumors In Young Jordanian Patients

2026-04-01

Abstract excerpt

<title>Abstract</title> <p> In Jordan, approximately 19% of colorectal carcinomas (CRCs) in patients younger than 45 years show mismatch repair deficiency (MMRD) by immunohistochemistry (IHC). MMRD in pediatric high-grade gliomas (HGG) and CRC in Jordan appears substantially more frequent than global estimates (39% and 44%, respectively), likely reflecting high consanguinity rates and an increased contribution o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 271bb6d1-7ff4-5dab-8fbf-6b70d73281d3
DOI: 10.21203/rs.3.rs-9017459/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular Characterization of Mismatch Repair Deficient Tumors In Young Jordanian PatientsDOI 10.21203/rs.3.rs-9017459/v1Read

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes.Semantic proximity Read

Position paper: Challenges and specific strategies for constitutional mismatch repair deficiency syndrome in low‐resource settingsSemantic proximity Read

Unraveling mutagenic processes influencing the tumor mutational patterns of individuals with constitutional mismatch repair deficiencySemantic proximity Read

The Challenge of Diagnosing Constitutional Mismatch Repair Deficiency Syndrome in Brain Malignancies from Young IndividualsSemantic proximity Read

DNA mismatch repair proteins: scientific update and practical guide.Semantic proximity Read

Mismatch Repair Status Characterization in Oncologic Pathology: Taking Stock of the Real-World PossibilitiesSemantic proximity Read

Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer OnsetSemantic proximity Read

Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in ChildhoodSemantic proximity Read

Clinical Updates and Surveillance Recommendations for DNA Replication Repair Deficiency Syndromes in Children and Young Adults.Semantic proximity Read

Mutation and Microsatellite Burden Predict Response to PD-1 Inhibition in Children with Germline DNA Replication Repair DeficiencySemantic proximity Read

Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: report from the constitutional mismatch repair deficiency consortium.Semantic proximity Read

Unveiling MMR deficiency in pediatric and AYA high-grade gliomas: insights from multiomic profiling.Semantic proximity Read