Article

Effect of MisMatch Repair Deficiency on metastasis occurrence modelized in a syngeneic mouse model

2024-12-03

Abstract excerpt

Mismatch repair deficiency leads to high mutation rates and microsatellite instability (MSI-H), associated with immune infiltration and responsiveness to immunotherapies. In early stages, MSI-H tumors generally have a better prognosis and lower metastatic potential than microsatellite-stable (MSS) tumors, especially in colorectal cancer. However, in advanced stages, MSI-H tumors lose this survival advantage for re...

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Literature Corpus work: bea12c6d-1791-5084-86b4-b2790f3e83d7
DOI: 10.1101/2024.11.29.626023

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