Article

Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance

2021-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Most cancer deaths result from progression of therapy resistant disease, yet our understanding of this phenotype is limited. Cancer therapies generate stress signals that act upon mitochondria to initiate apoptotic programs. We isolated mitochondria from neuroblastoma cell lines obtained from children at diagnosis and after relapse following failed therapy, and profiled responses to tBid and Bim...

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Literature Corpus work: bddcb8ba-e8b0-5a3f-a26c-4adee63bbb2b
DOI: 10.1101/2021.03.01.433120

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