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Dynamic Control of Mitochondrial Ca2+ Levels as a Survival Strategy of Cancer Cells

4 Feb 2021

Abstract excerpt

Cancer cells have increased energy requirements due to their enhanced proliferation activity. This energy demand is, among others, met by mitochondrial ATP production. Since the second messenger Ca 2+ maintains the activity of Krebs cycle dehydrogenases that fuel mitochondrial respiration, proper mitochondrial Ca 2+ uptake is crucial for a cancer cell survival. However, a mitochondrial Ca 2+ overload induces...

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PMID: 33614647
DOI: 10.3389/fcell.2021.614668

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