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Article

Bcl-2: A Prime Regulator of Mitochondrial Redox Metabolism in Cancer Cells

16 May 2011

Abstract excerpt

SIGNIFICANCE: Mitochondria play a critical role as death amplifiers during drug-induced apoptosis in cancer cells by providing pro-apoptotic factors that are released from the mitochondrial inter-membranous space upon the induction of mitochondrial outer membrane permeabilization. This intrinsic death signaling pathway is the preferred mechanism employed by most anticancer compounds, and as such, resistance to...

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PMID: 21574773
DOI: 10.1089/ars.2010.3851

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