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Conserved <i>cis</i> and <i>trans</i> communication domains mediate module interaction in glycopeptide antibiotic NRPS assembly lines

2026-08-07

Abstract excerpt

Non-ribosomal peptide synthetases (NRPSs) assemble structurally complex and clinically important natural products, yet the mechanisms coordinating communication between multiple enzymes remain incompletely understood. Here, we dissected the NRPS system underlying biosynthesis of the glycopeptide antibiotic (GPA) balhimycin in Amycolatopsis balhimycina to elucidate principles of inter-enzyme communication. Genetic...

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Literature Corpus work
4425fca9-7dc2-5ecd-8ad1-644886ab7c15
DOI
10.64898/2026.08.07.743486
Open publication

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Conserved <i>cis</i> and <i>trans</i> communication domains mediate module interaction in glycopeptide antibiotic NRPS assembly linesDOI 10.64898/2026.08.07.743486
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