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Article

Cryo-EM structure of the Nisin resistance pump PsdAB reveals an unusual ABC transporter architecture.

Structure (London, England : 1993) - 5 Feb 2026

He Yutong, Fan Wenjie, Shi Jian, Gan Bee Koon, Shao Kai, Zhu Fan, Hong Xuechuan, Luo Min

Abstract excerpt

Bacteria have evolved diverse strategies to resist antimicrobial peptides, among them lipid II-targeting lantibiotics such as nisin. PsdAB, an ABC-type transporter regulated by the PsdRS two-component system, contributes to nisin resistance, though its structural and mechanistic basis have remained unclear. Here, we report the cryo-EM structure of Bacillus subtilis PsdAB, revealing a dimeric assembly with an...

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PMID: 41418778
DOI: 10.1016/j.str.2025.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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