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GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery

16 Oct 2020

Abstract excerpt

Glycopeptide antibiotics (GPAs) are essential for the treatment of severe infectious diseases caused by Gram-positive bacteria. The emergence and spread of GPA resistance have propelled the search for more effective GPAs. Given their structural complexity, genetic intractability, and low titer, expansion of GPA chemical diversity using synthetic or medicinal chemistry remains challenging. Here we describe a...

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PMID: 33067466
DOI: 10.1038/s41467-020-19138-5

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