Article

Structural determinants of endopilus assembly, stability and functional specificity in bacterial type II secretion

2026-04-12

Abstract excerpt

Gram-negative bacteria employ the type II secretion system (T2SS) to transport folded protein effectors across the outer membrane. This multiprotein nanomachine assembles the endopilus, a periplasmic helical polymer composed of one major and four minor pilin subunits. Endopili are structurally related to type IV pili but exhibit distinct features including a conserved calcium-binding site stabilizing their major p...

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Literature Corpus work: 0e8a0749-af18-5fd1-bef2-38b119672dc5
DOI: 10.64898/2026.04.10.717868

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