Article
Intron-mediated enhancement boosts Rtn4 circRNA expression: A robust method for exploring circRNA function
2018-01-30
Abstract excerpt
CircRNAs are expressed in many important biological processes. Studying their function requires an effective expression method. When we used intron-mediated enhancement (IME) to improve circRNA expression of mouse Rtn4 (Nogo, a key protein in Nogo-Rho pathways) circRNA as a test case, we achieved a 4-6-fold improvement compared to an existing method. We further developed this approach into a general circRNA expres...
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Identifiers and source
- Literature Corpus work
- 44246956-632c-5e0d-8575-398f8c7414d0
- DOI
- 10.1101/257105