3’ to 5’ Translation of Circular RNAs?

Abstract excerpt

For decades, the 5’→3’ direction of translation has been a central dogma of molecular biology( 1 ). Here we present evidence that eukaryotic circular RNAs (circRNAs) can serve as templates for 3’→5’ backward translation (BT), yielding polypeptides with distinct sequence and structural features not found in canonical proteomes. Mining of more than 6,000 multi-omics datasets identified ∼1 million candidate BT prote...

Topics

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• Gene Expression Regulation, Neoplastic
• HEK293 Cells
• HeLa Cells
• Nucleic Acid Conformation
• Protein Biosynthesis
• Receptor, Fibroblast Growth Factor, Type 1
• RNA, Circular
• Structure-Activity Relationship

Identifiers and source

Literature Corpus work

ec285dcf-b9dc-5028-b74d-a71109f47170

DOI

10.64898/2025.12.08.692888