Synthetic circRNAs employ IRES activity for translation in cells and in cell-free translation systems

Abstract excerpt

<h4>ABSTRACT</h4> Gene regulation through translation is critical for spatiotemporal protein expression. Internal ribosomal entry sites (IRESes) mediate mRNA-specific translation by recruiting ribosomes to 5′ untranslated regions. Circular RNAs (circRNAs), naturally occurring and stable RNAs, are increasingly used as synthetic tools for sustained therapeutic protein translation by IRES-driven initiation. However,...

Topics

Open a Topic to create a Post that cites this publication.

• Gene Expression Regulation, Neoplastic
• HEK293 Cells
• HeLa Cells
• Nucleic Acid Conformation
• Protein Biosynthesis
• Receptor, Fibroblast Growth Factor, Type 1
• RNA, Circular
• Structure-Activity Relationship

Identifiers and source

Literature Corpus work

00f8c95a-3a24-591b-be0a-912e5271eec1

DOI

10.64898/2026.03.28.715045