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Deciphering functional redundancy and energetics of malate oxidation in mycobacteria

23 Mar 2022

Abstract excerpt

Oxidation of malate to oxaloacetate, catalyzed by either malate dehydrogenase (Mdh) or malate quinone oxidoreductase (Mqo), is a critical step of the tricarboxylic acid cycle. Both Mqo and Mdh are found in most bacterial genomes, but the level of functional redundancy between these enzymes remains unclear. A bioinformatic survey revealed that Mqo was not as widespread as Mdh in bacteria but that it was highly...

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PMID: 35337802
DOI: 10.1016/j.jbc.2022.101859

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