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Article

The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei.

Biochimica et biophysica acta. Bioenergetics - 1 Nov 2020

Mochizuki Kota, Inaoka Daniel Ken, Mazet Muriel, Shiba Tomoo, Fukuda Keisuke, Kurasawa Hana, Millerioux Yoann, Boshart Michael, Balogun Emmanuel O, Harada Shigeharu, Hirayama Kenji, Bringaud Frédéric, Kita Kiyoshi

Abstract excerpt

Acetate:succinate CoA transferase (ASCT) is a mitochondrial enzyme that catalyzes the production of acetate and succinyl-CoA, which is coupled to ATP production with succinyl-CoA synthetase (SCS) in a process called the ASCT/SCS cycle. This cycle has been studied in Trypanosoma brucei (T. brucei), a pathogen of African sleeping sickness, and is involved in (i) ATP and (ii) acetate production and proceeds...

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Identifiers

PMID: 32763239
DOI: 10.1016/j.bbabio.2020.148283
PMCID: PMC7402102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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