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Protein interaction analysis of <i>Plasmodium falciparum</i> circumsporozoite protein variants with human immunoproteins explains RTS,S vaccine efficacy in Ghana

2021-12-30

Abstract excerpt

<h4>Background</h4> The world’s first malaria vaccine RTS,S provides only partial protection against Plasmodium falciparum infections. The explanation for such low efficacy is unclear. This study examined the associations of parasite genetic variations with binding affinity to human immunological proteins including human leukocyte antigen (HLA) and T cell receptors (TCR) involved in RTS,S-induced immune response...

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Literature Corpus work
4413e421-1afd-5d39-adbb-39b282d390b5
DOI
10.1101/2021.12.29.474460
Open publication

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