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Article

Population genetic analysis of the Plasmodium falciparum circumsporozoite protein in two distinct ecological regions in Ghana.

Malaria journal - 27 Nov 2020

Amegashie Elikplim A, Amenga-Etego Lucas, Adobor Courage, Ogoti Peter, Mbogo Kevin, Amambua-Ngwa Alfred, Ghansah Anita

Abstract excerpt

BACKGROUND: Extensive genetic diversity in the Plasmodium falciparum circumsporozoite protein (PfCSP) is a major contributing factor to the moderate efficacy of the RTS,S/AS01 vaccine. The transmission intensity and rates of recombination within and between populations influence the extent of its genetic diversity. Understanding the extent and dynamics of PfCSP genetic diversity in different transmission settings...

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Identifiers

PMID: 33246470
DOI: 10.1186/s12936-020-03510-3
PMCID: PMC7694917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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