Article
Genetic variations of Plasmodium falciparum circumsporozoite protein and the impact on interactions with human immunoproteins and malaria vaccine efficacy.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2023
Dieng Cheikh Cambel, Ford Colby T, Lerch Anita, Doniou Dickson, Vegesna Kovidh, Janies Daniel, Cui Liwang, Amoah Linda, Afrane Yaw, Lo Eugenia
Abstract excerpt
In October 2021, the world's first malaria vaccine RTS,S was endorsed by WHO for broad use in children, despite its low efficacy. This study examined polyclonal infections and the associations of parasite genetic variations with binding affinity to human leukocyte antigen (HLA). Multiplicity of infection was determined by amplicon deep sequencing of PfMSP1. Genetic variations in PfCSP were examined across 88...
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