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Article

Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm.

International journal of molecular sciences - 31 Aug 2020

Gurung Rijan, Choong Andrew Mark, Woo Chin Cheng, Foo Roger, Sorokin Vitaly

Abstract excerpt

Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of the extracellular matrix (ECM), vascular inflammation, and oxidative stress are hallmarks of AAA pathogenesis and contribute to the progressive thinning of the media and adventitia of the aortic wall. With increasing AAA diameter,...

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Share to Aortic Aneurysm, Abdominal
Share to Aortic aneurysm repair treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Disease and Treatment Approaches

Share to Epigenesis, Genetic

Share to Gene Expression Regulation

Share to Muscle, Smooth, Vascular

Share to Phenotype

Source

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Identifiers

PMID: 32878347
DOI: 10.3390/ijms21176334
PMCID: PMC7504666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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