Article

AI-designed AAV capsids deliver high-efficiency muscle gene transfer for low-dose therapy

2026-05-08

Abstract excerpt

<title>Abstract</title> <p>Muscular dystrophies are debilitating genetic disorders with no curative therapies. While AAV vectors offer promise, current capsids remain limited by pre-existing immunity, high-dose-induced toxicity, and manufacturing burden. We and others recently demonstrated that cross-species myotropism can be achieved by redirecting AAV tropism toward the conserved receptor αVβ6 integrin. Here, w...

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Literature Corpus work: bc00aad5-33bf-5e90-8444-8004c8b35dfd
DOI: 10.21203/rs.3.rs-9629847/v1

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