Article

Structural dynamics insights into principles underlying the fitness of new broadly potent AAVs

2026-03-25

Abstract excerpt

Adeno-associated virus (AAV) is a leading platform for gene therapy, but current clinical-stage vectors require high doses associated with adverse events. Engineering of AAVs has produced more efficient vectors, although the mechanism underlying these improvements often remains poorly understood, limiting further development and raising potential safety concerns. Here, we leveraged a new workflow for AAV engineeri...

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Identifiers and source

Literature Corpus work: e83b9fc3-c32a-556f-b75e-77e969510042
DOI: 10.64898/2026.03.24.713814

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