Article

The chromatin remodeler ISWI acts during <i>Drosophila</i> development to regulate adult sleep

2020-08-12

Abstract excerpt

Sleep disruptions are among the most commonly-reported symptoms across neurodevelopmental disorders (NDDs), but mechanisms linking brain development to normal sleep are largely unknown. From a Drosophila screen of human NDD-associated risk genes, we identified the chromatin remodeler Imitation SWItch/SNF ( ISWI ) to be required for adult fly sleep. Loss of ISWI also results in disrupted circadian rhythms, memo...

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Literature Corpus work: 289f0a4a-e992-5498-8375-10a33b4a2b79
DOI: 10.1101/2020.08.11.247080

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