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Intronic elements associated with insomnia and restless legs syndrome exhibit cell type-specific epigenetic features contributing to <i>MEIS1</i> regulation

2021-09-05

Abstract excerpt

<h4>ABSTRACT</h4> A highly evolutionarily conserved MEIS1 intronic region is strongly associated with restless legs syndrome (RLS) and insomnia. To understand its regulatory function, we dissected the region by analyzing chromatin accessibility, enhancer-promoter contacts, DNA methylation, and eQTLs in different human neural cell types and tissues. We observed specific activity with respect to cell type and deve...

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Identifiers and source

Literature Corpus work
3376d383-5919-5456-8b5b-e7686cb8edb4
DOI
10.1101/2021.09.03.458823
Open publication

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Intronic elements associated with insomnia and restless legs syndrome exhibit cell type-specific epigenetic features contributing to <i>MEIS1</i> regulationDOI 10.1101/2021.09.03.458823
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