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Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity

2024-10-11

Abstract excerpt

<h4>ABSTRACT</h4> It is of critical importance to our understanding of Alzheimer’s disease (AD) pathology to determine how key pathological factors are interconnected and implicated in nerve cell death, clinical symptoms, and disease progression. The formation of extracellular beta-amyloid (Aβ) plaques is the major pathological hallmark of AD and Aβ has been suggested to be a critical inducer of AD, driving disea...

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Literature Corpus work
834fdecc-74a0-5e11-911d-0f376d2abc8a
DOI
10.1101/2024.10.08.617019
Open publication

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Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased ToxicityDOI 10.1101/2024.10.08.617019
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