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Article

Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome.

Behavioural brain research - 1 Oct 2011

Thomas Alexia M, Bui Nghiem, Graham Deanna, Perkins Jennifer R, Yuva-Paylor Lisa A, Paylor Richard

Abstract excerpt

INTRODUCTION: Genetic heterogeneity likely contributes to variability in the symptoms among individuals with fragile X syndrome (FXS). Studies in the Fmr1 knockout (KO) mouse model for FXS suggest that excessive signaling through group I metabotropic glutamate receptors (Gp1 mGluRs), comprised of subtypes mGluR1 and mGluR5, may play a role. Hence, Gp1 mGluRs may act as modifiers of FXS. Currently no studies have...

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Identifiers

PMID: 21571007
DOI: 10.1016/j.bbr.2011.04.049
PMCID: PMC3142659

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