Article

Single Nuclei-Derived Molecular Subtypes of Gastrointestinal Stromal Tumors Correlate with Clinicopathologic Features and Predict Clinical Outcomes

2025-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Historically, gastrointestinal stromal tumor (GIST) has been subtyped by oncogenic driver mutations. However, tumors with the same mutational profile can have variable biology. To further explore the impact of molecular diversity on GIST biology, we performed single nucleus RNA sequencing on 16 primary GIST and utilized an integrated single cell atlas of the normal GI tract composed from multipl...

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Literature Corpus work: b79c8050-d8ab-5680-8540-3f4443d2a4b5
DOI: 10.1101/2025.04.21.647322

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