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Article

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

2019-05-18

Abstract excerpt

Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated across the ESCC genome and two-thirds occur in long non-coding (lnc)RNA regions. DNA methylation and epigenetic heterogeneity both coincide with chromosomal topological...

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Literature Corpus work
939bf460-43ff-5b4b-80cf-e211dd1ab44a
DOI
10.1101/641357
Open publication

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