Article

Integrative Multi-omics Guides PD-1 Blockade Therapy in the Rare and Aggressive Colorectal Adenosquamous Carcinoma

2026-03-24

Abstract excerpt

<title>Abstract</title> <p>Colorectal adenosquamous carcinoma (CRASC) is a rare and aggressive malignancy without standardized treatment, posing a grave clinical challenge. Here, we performed integrative multi-omics analysis on the largest multicenter cohort to date, to delineate its molecular and spatial architecture. Whole-exome sequencing showed that adenocarcinoma (AC) and squamous cell carcinoma (SCC) compon...

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Literature Corpus work: 7ff12ad7-daf8-5115-8f24-a773f51c6d0d
DOI: 10.21203/rs.3.rs-8826108/v1

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