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Article

Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor.

Cancer research - 1 Jun 2011

Manshouri Taghi, Estrov Zeev, Quintás-Cardama Alfonso, Burger Jan, Zhang Ying, Livun Ana, Knez Liza, Harris David, Creighton Chad J, Kantarjian Hagop M, Verstovsek Srdan

Abstract excerpt

Signals emanating from the bone marrow microenvironment, such as stromal cells, are thought to support the survival and proliferation of the malignant cells in patients with myeloproliferative neoplasms (MPN). To examine this hypothesis, we established a coculture platform [cells cocultured directly (cell-on-cell) or indirectly (separated by micropore membrane)] designed to interrogate the interplay between Janus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21512135
DOI: 10.1158/0008-5472.CAN-10-4002
PMCID: PMC4067142

Genes

JAK2
SET
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor.PMID 21512135Read ↗

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