Article

Loss-of-Function Mutations in the Penicillin-Binding Protein PonA1 Confer Agar-Dependent Resistance to Durlobactam in <em>Mycobacterium abscessus</em>

2025-11-24

Abstract excerpt

<h4>Background: </h4> Infections caused by the multidrug-resistant pathogen Mycobacterium abscessus (Mab) are notoriously difficult to treat. The novel β-lactamase inhibitor durlobactam, in combination with β-lactams, shows potent bactericidal activity against Mab, but the potential for acquired resistance remains a clinical concern. <h4>Objectives:</h4> To identify and characterize mechanisms of acquired resistan...

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Literature Corpus work: d1c38d9e-7699-5b4a-94af-4abc2e0d3f5b
DOI: 10.20944/preprints202511.1728.v1

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