Article

CRISPR/Cas9-mediated knockout of IL1RAPL1 in stem cells highlights a role in neural cell migration during cortical development

2022-11-30

Abstract excerpt

<title>Abstract</title> Genetic risk factors contribute to cortical developmental abnormalities observed in a range of neurodevelopmental disorders including autism and schizophrenia. Emerging evidence suggests that <italic>IL1RAPL1</italic>is a common risk gene across many neurodevelopmental disorders. We combined CRISPR gene editing with induced pluripotent stem cell derived neuronal and microglia model syst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4362a376-da19-5ae7-a685-d304f812c7c6
DOI: 10.21203/rs.3.rs-2326773/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR/Cas9-mediated knockout of IL1RAPL1 in stem cells highlights a role in neural cell migration during cortical developmentDOI 10.21203/rs.3.rs-2326773/v1Read

CRISPR screens in 3D assembloids reveal disease genes associated with human interneuron developmentSemantic proximity Read

Copy Number Variation at 16p11.2 Imparts Transcriptional Alterations in Neural Development in an hiPSC-derived Model of CorticogenesisSemantic proximity Read

A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease statesSemantic proximity Read

De novo MAP2K4 variants cause a novel neurodevelopmental syndrome with impaired JNK signaling in iPSC-derived neuronsSemantic proximity Read

Loss of function in the autism and schizophrenia-associated gene CYFIP1 in human microglia supports a role in synaptic pruningSemantic proximity Read

Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activationSemantic proximity Read

Generation of a heterozygous and a homozygous CSF1R knockout line from iPSC using CRISPR/Cas9.Semantic proximity Read

Disrupted glial-mediated synaptic refinement in Fragile X syndromeSemantic proximity Read

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1 -related intellectual disabilitySemantic proximity Read

Stem cell derived neurosphere assay highlights the effects of infection on human cortical developmentSemantic proximity Read

Autism and Intellectual Disability-Associated MYT1L Mutation Alters Human Cortical Interneuron Differentiation, Maturation, and PhysiologySemantic proximity Read

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.Semantic proximity Read