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Autism and Intellectual Disability-Associated <i>MYT1L</i> Mutation Alters Human Cortical Interneuron Differentiation, Maturation, and Physiology

2024-09-12

Abstract excerpt

<h4>SUMMARY</h4> MYT1L is a neuronal transcription factor highly expressed in the developing and adult brain. While pathogenic MYT1L mutation causes neurodevelopmental disorders, these have not been characterized in human models of neurodevelopment. Here, we defined the consequences of pathogenic MYT1L mutation in human pluripotent stem cell-derived cortical interneurons. During differentiation, mutation reduce...

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Literature Corpus work
4ce3ac1a-30d2-5226-9a05-464d244da45b
DOI
10.1101/2024.09.11.612541
Open publication

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Autism and Intellectual Disability-Associated <i>MYT1L</i> Mutation Alters Human Cortical Interneuron Differentiation, Maturation, and PhysiologyDOI 10.1101/2024.09.11.612541
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