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Article

LIN28A loss of function is associated with Parkinson's disease pathogenesis.

The EMBO journal - 16 Dec 2019

Chang Mi-Yoon, Oh Boram, Choi Jang-Eun, Sulistio Yanuar Alan, Woo Hye-Ji, Jo Ayoung, Kim Jinil, Kim Eun-Hee, Kim Seung Won, Hwang Jungwook, Park Jungyun, Song Jae-Jin, Kwon Oh-Chan, Henry Kim Hyongbum, Kim Young-Hoon, Ko Joo Yeon, Heo Jun Young, Lee Min Joung, Lee Moses, Choi Murim, Chung Sun Ju, Lee Hyun-Seob, Lee Sang-Hun

Abstract excerpt

Parkinson's disease (PD) is neurodegenerative movement disorder characterized by degeneration of midbrain-type dopamine (mDA) neurons in the substantia nigra (SN). The RNA-binding protein Lin28 plays a role in neuronal stem cell development and neuronal differentiation. In this study, we reveal that Lin28 conditional knockout (cKO) mice show degeneration of mDA neurons in the SN, as well as PD-related behavioral...

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Identifiers

PMID: 31750563
DOI: 10.15252/embj.2018101196
PMCID: PMC6912061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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