Article
Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.
Development (Cambridge, England) - 1 Apr 2015
Metzakopian Emmanouil, Bouhali Kamal, Alvarez-Saavedra Matías, Whitsett Jeffrey A, Picketts David J, Ang Siew-Lan
Abstract excerpt
Midbrain dopamine neuronal progenitors develop into heterogeneous subgroups of neurons, such as substantia nigra pars compacta, ventral tegmental area and retrorubal field, that regulate motor control, motivated and addictive behaviours. The development of midbrain dopamine neurons has been extensively studied, and these studies indicate that complex cross-regulatory interactions between extrinsic and intrinsic...
Topics
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Binding Sites
- Cell Differentiation
- DNA-Binding Proteins
- Dopaminergic Neurons
- Embryo, Mammalian
- Enhancer Elements, Genetic
- Gene Expression Regulation, Developmental