Article

Nuclear Factor Kappa B Over-Activation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc Degeneration

2023-08-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Low back pain (LBP) is the leading cause of global disability and is thought to be driven primarily by intervertebral disc (IVD) degeneration (DD). Persistent upregulation of catabolic enzymes and inflammatory mediators have been associated with severe cases of DD. Nuclear factor kappa B (NF-κB) is a master transcription regulator of immune responses and is over expressed dur...

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Literature Corpus work: 431d5f60-f94e-54f4-ac43-af99e5126d5c
DOI: 10.1101/2023.08.07.552274

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